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ȱƶѪԤ



ƶѪΪܶ࣬ѪƶѪϰƶѪȱƶѪȡ죬ҪҽйȱƶѪԤķҶ˵Ҳ֪ѪҺҪԣ˽ƶѪԤǶǷdzҪģϣáһ༰򡡡ڲͬٴص㣬ƶѪвͬķࡣ磺ƶѪչٶȷּƶѪϸִ̬ϸƶѪϸƶѪСϸɫƶѪѪ쵰ŨȷȡжȡضȺͼضƶѪϵƶѪѪƶѪȱƶѪϸƶѪȣƶѪϰƶѪٴϳƶѪƺͲķࣺ1.ϸɼƶѪѪϸѪ΢Ѫԭϵ쳣ӰϸɣγɺϸɼƶѪ1Ѫϸ쳣ƶѪ1ϰƶѪAAAAһֹѪ˥֢ԭͼ̷ѪϸйءȫѪϸ֢ķBϸϸ壬ƻƹѪϸйء2ϸϰƶѪPRCAPRCAָϵѪϸܵ𺦣ƶѪݲ򣬸òɷΪԺͺࡣPRCADiamond-BlackfanۺϵŴ£PRCAԭ̷ࡣѧ߷ֲԭPRCAѪEPO׺ϸ塣̷PRCAҪҩ͡ȾͣϸͲ΢СB19ײȣ߲ܰ͡ϸֳԼͣܰϸܰϸѪȣԼϰΣȡ3Ժϸ쳣ƶѪCDACDAһŴԺϵϸԿ¡쳣µġԺϵЧѪ̬쳣ΪƶѪŴʽòɷΪȾɫŴͺŴ͡4ѪϵͳԿ¡ԼЩѪϸʵ쳣쳣ۺѪϵͳԼѪȡǰΪ̬ѪߵԭλѪ͵͵ͷֻѪҲܵӰ죬ӶʹϸٶƶѪ2Ѫ΢쳣ƶѪѪ΢ʣϸϸӡ1ʺͻϸƶѪ軵άӲ֢ʯԼĹתԼָȾǸȾԹף˹ʺͻϸѪ΢쳣ӰѪϸɡ2Ѫˮƽ쳣ƶѪϸӣSCFϸأIL-ϵ̼ӣGM-CSFϵ̼ӣG-CSFϸأEPOѪСأTPOѪСӣTGFӣTNF͸أIFNȾѪáܲȫβʹ״ٹܵµʱEPO㣻ԼijЩȾյ϶ѪTNFIFN֢ӵȣɵԲƶѪACD3)ѪԭϲϰƶѪѪԭָѪϸֳֻлʣ絰ʡ֬ࡢάأҶᡢάB12ȣ΢ԪأͭпȣȡһѪԭϲϰܵºϸɼ١1ҶάB12ȱϰƶѪڸص»ҶάB12ԻȱϰľϸƶѪ2ȱϰƶѪٴƶѪȱϰӰѪغϳɣгƸƶѪΪѪغϳ쳣ƶѪƶѪĺϸ̬С뵭ȾСϸɫƶѪ2.ѪƶѪHAϸƻƶѪ3.ʧѪƶѪʧѪٶȷּԺԣʧѪƶѪϲȱƶѪɷΪѪԼطѪС񰡢ѪѲظβȣºͷdzѪԼˡˡ֧š̺͸Ƽȣࡣٴ֡ƶѪIJѪҺЯ½ij̶ȣѪ½ij̶ȣƶѪٶȺѪҺѭϵͳĴӰƶѪٴ֡1.ϵͳͷ衢ͷʹʧߡΡˡעеȣƶѪȱ֯³֢״СƶѪʱɿֲ궯Ӱ2.ƤĤ԰ƶѪʱƤĤҪ֡ƶѪʱͨҺڽЧѪ·䣬ԴҪƤĤѪ٣⣬ڵλݻѪҺںϸѪ쵰׺٣ҲƤĤɫ䵭ֲڡȱٹγƶѪʱƤĤһ֣ܻƶѪԭйءѪƶѪرѪѪƶѪƤĤȾ3.ѭϵͳƶѪʱϸںϳɽ϶23-ᣨ23-DPGԽѪ쵰׶׺ʹƣ֯øѣں̼Ѫ֢¡ƶѪԱ֣ӿļ¡ʼӿ졣ƶѪأ֢״ԡضƶѪʱʹƽ״̬ҲƶѪ೬ɹҹ㣬ᵼƶѪಡʱʱ仯ʧĹܲȫ4.ϵͳƶѪʱٷڼήָܼ͡ʳ͡ɺ״ĸıȡѪɺϲʯƢȱƶѪл֢ϸƶѪƶѪסήţࡢȡ5.ֳڷϵͳѪѪ޵صĸԭѪѪѪ쵰ͺѪɷѪ쵰׶Сܣ򡢼˥ߡƶѪӰغͪķڣŮԣӰŮԼصķڶ¾쳣վ¾ࡣŮ˾ƶѪӰڷĹܺͺϸصķڡ3顡1.Ѫ顡ƶѪƶѪس̶ȣǷϸѪСı仯ݺϸMCVMCHMCHCɶƶѪкϸ̬࣬Ϊṩ֯ϸӷӳϵѪͿƬɹ۲ϸϸѪС̬ı䣬зűԭ쳣ϸȡ2.顡ϸͿƬӳϸ̶ȡϸɷ̬֡仯췴ӳѪ֯Ľṹ̶ȡϸɷֺ̬仯ijЩƶѪѪ軵άʯ䣬ϸȾϼֵעȡľԣѪìʱӦಿλ顣ƶѪķƼ顡ȱƶѪлȱԭ飻ϸƶѪѪҶάB12ˮƽⶨ´Ѫԭȱԭ飻ʧѪƶѪԭ飻ѪƶѪɷѪ쵰ߡ鵰׽͡ѪߡӵߵȡʱкϸĤø鵰סѪء塢ֿͬPNH¡ȼ飻ѪϸȾɫ塢ԭϸڡȼ飻ԼTϸȺڵӻϸȡ˵ףʵԤƶѪܼ򵥣ֻҪƽʱճжעʳϰߣ֤ӪӦÿ쵽ܣ˶ȵȣԤƶѪdzЧֶΡȻѾƶѪˣҪĿ϶ǵҽԺҽҽָ½иơ

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